VDR antibody (pAb)

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

WB

Cat No : 61555,61556

Synonyms

VDR, Vitamin D (1,25- Dihydroxyvitamin D3) Receptor, Nuclear Receptor Subfamily 1 Group I Member 1, 1,25-Dihydroxyvitamin D3 Receptor, NR1I1, Vitamin D Nuclear Receptor Variant 1, Vitamin D3 Receptor, transcription, winac complex, baz1b/wstf, pab, polyclonal, antibody, western blotting, wb, sample

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Validation Data Gallery

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  VDR antibody (pAb) tested by Western blot. Nuclear extract of LoVo cells (30 ug) probed with VDR antibody (pAb) at a dilution of 1:500.

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Product Information

• Tested Applications: WB

  Applications Validated by Active Motif: WB: 1:500 - 1:1,000 dilution The addition of 0.05% Tween 20 in the blocking buffer and primary antibody incubation buffer is recommended to aid in detection by Western blot. Individual optimization may be required.

• Tested Reactivity: Human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: This antibody was raised against a peptide within the C-terminal region of human VDR.
• Full Name: VDR antibody (pAb)
• Synonyms: VDR, Vitamin D (1,25- Dihydroxyvitamin D3) Receptor, Nuclear Receptor Subfamily 1 Group I Member 1, 1,25-Dihydroxyvitamin D3 Receptor, NR1I1, Vitamin D Nuclear Receptor Variant 1, Vitamin D3 Receptor, transcription, winac complex, baz1b/wstf, pab, polyclonal, antibody, western blotting, wb, sample
• Molecular weight: 50 kDa
• GenBank accession number: NP_001017535
• RRID: AB_2614966
• Purification Method: Affinity Purified
• Buffer: Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
• Storage: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Background Information

VDR (vitamin D receptor) is a Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.