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TLR8 antibody (mAb) (Clone 44C143)

Host / Isotype

Mouse / IgG1

Reactivity

Human, Mouse

Applications

WB

CloneNo.

44C143

Activ Motif logo

Cat No : 40955 40955

Synonyms

TLR8, TLR-8, TLR 8, mAb, monoclonal, antibody, antibodies

Validation Data Gallery

  • TLR8 mAb tested by Western blot. TLR8 detection by Western blot. The analysis was performed using TLR8 mAb and nuclear extract from 293 cells that had been transfected with human TLR8 cDNA.

    TLR8 mAb tested by Western blot. TLR8 detection by Western blot. The analysis was performed using TLR8 mAb and nuclear extract from 293 cells that had been transfected with human TLR8 cDNA.

Product Information

Tested Applications WB

Applications Validated by Active Motif: WB: 1 - 2 ug/ml dilution For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all blocking solutions may also reduce background. Individual optimization may be required.
Tested Reactivity Human, Mouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen This TLR8 antibody was raised against a peptide corresponding to amino acid residues 750-850 of human TLR8.
Full Name TLR8 antibody (mAb) (Clone 44C143)
Synonyms TLR8, TLR-8, TLR 8, mAb, monoclonal, antibody, antibodies
Molecular weight 120 kDa
GenBank accession numberNP_619542
RRIDAB_2793456
Purification Method Affinity Purified
Buffer PBS containing 0.02% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Background Information

TLR8 – Toll-Like receptor 8 is a member of the Toll-like receptor (TLR) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize specific molecular features associated with pathogens, and mediate the production of cytokines necessary for the development of effective immunity. Many of the TLRs heterodimerize with each other to modulate receptor function. TLR8 expression cells is elevated after exposure to both Gram-positive and Gram-negative bacteria. While primarily extracellular, TLR8 may be also localized intracellularly.