• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

TLR3 antibody (mAb) (Clone 40C1285)

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB

CloneNo.

40C1285

Activ Motif logo

Cat No : 40952 40952

Synonyms

TLR3, TLR-3, TLR 3, mAb, monoclonal, antibody, antibodies

Validation Data Gallery

  • TLR3 mAb tested by Western blot. TLR3 detection by Western blot. The analysis of TLR3 was performed using TLR3 mAb and nuclear extract from 293 cells (lane 1) and nuclear extract from 293 cells that had been transfected with human TLR3 cDNA (lane 2).

    TLR3 mAb tested by Western blot. TLR3 detection by Western blot. The analysis of TLR3 was performed using TLR3 mAb and nuclear extract from 293 cells (lane 1) and nuclear extract from 293 cells that had been transfected with human TLR3 cDNA (lane 2).

Product Information

Tested Applications WB

Applications Validated by Active Motif: WB: 1 - 2 ug/ml dilution For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all blocking solutions may also reduce background. Individual optimization may be required.
Tested Reactivity Human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen This TLR3 antibody was raised against a KLH-conjugated synthetic peptide corresponding to human TLR3.
Full Name TLR3 antibody (mAb) (Clone 40C1285)
Synonyms TLR3, TLR-3, TLR 3, mAb, monoclonal, antibody, antibodies
Molecular weight 120 kDa
GenBank accession numberAAH59372
RRIDAB_2793454
Purification Method Affinity Purified
Buffer PBS containing 0.02% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Background Information

TLR3 – Toll-Like receptor 3 is a member of the Toll-like receptor (TLR) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize specific molecular features associated with pathogens, and mediate the production of cytokines necessary for the development of effective immunity. Many of the TLRs heterodimerize with each other to modulate receptor function. TLR3 expression is increased after exposure to Gram-negative bacteria and to an even greater extent in response to Gram-positive bacteria. TLR3 forms a homodimer and recognizes viral double stranded RNA (dsRNA).