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TEAD1 antibody (pAb)

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

WB

Activ Motif logo

Cat No : 61643,61644 61643

Synonyms

TEAD1, TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor), REF1, TCF13, Atrophia Areata Peripapillary Chorioretinal Degeneration, AA, TEF-1, Protein GT-IIC, Transcriptional Enhancer Factor 1, Transcription Factor 13, Transcriptional Enhancer Factor TEF-1, NTEF-1, TEF1, TCF-13, TEA Domain Family Member 1, TEAD-1, antibody, antibodies, polyclonal, pab, western blotting, wb, sample

Validation Data Gallery

  • TEAD1 antibody (pAb) tested by Western blot. Detection of TEAD1 by Western blot analysis. Nuclear extract of JEG cells (30 ug) probed with TEAD1 antibody at a dilution of 1:500.

    TEAD1 antibody (pAb) tested by Western blot. Detection of TEAD1 by Western blot analysis. Nuclear extract of JEG cells (30 ug) probed with TEAD1 antibody at a dilution of 1:500.

Product Information

Tested Applications WB

Applications Validated by Active Motif: WB: 1:500 - 1:1,000 dilution The addition of 0.05% Tween 20 in the blocking buffer and primary antibody incubation buffer is recommended to aid in detection by Western blot.
Tested Reactivity Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen This antibody was raised against a recombinant protein fragment within human TEAD1.
Full Name TEAD1 antibody (pAb)
Synonyms TEAD1, TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor), REF1, TCF13, Atrophia Areata Peripapillary Chorioretinal Degeneration, AA, TEF-1, Protein GT-IIC, Transcriptional Enhancer Factor 1, Transcription Factor 13, Transcriptional Enhancer Factor TEF-1, NTEF-1, TEF1, TCF-13, TEA Domain Family Member 1, TEAD-1, antibody, antibodies, polyclonal, pab, western blotting, wb, sample
Molecular weight 60 kDa
GenBank accession numberNP_068780
RRIDAB_2793717
Purification Method Affinity Purified
Buffer Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Background Information

TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor)) is a transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.