TEAD1 antibody (pAb)
Host / Isotype
Rabbit / IgG
Reactivity
Human
Applications
WB
Cat No : 61643,61644 61643
Synonyms
Validation Data Gallery
Product Information
Tested Applications |
WB
Applications Validated by Active Motif: WB: 1:500 - 1:1,000 dilution The addition of 0.05% Tween 20 in the blocking buffer and primary antibody incubation buffer is recommended to aid in detection by Western blot. |
Tested Reactivity | Human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | This antibody was raised against a recombinant protein fragment within human TEAD1. |
Full Name | TEAD1 antibody (pAb) |
Synonyms | TEAD1, TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor), REF1, TCF13, Atrophia Areata Peripapillary Chorioretinal Degeneration, AA, TEF-1, Protein GT-IIC, Transcriptional Enhancer Factor 1, Transcription Factor 13, Transcriptional Enhancer Factor TEF-1, NTEF-1, TEF1, TCF-13, TEA Domain Family Member 1, TEAD-1, antibody, antibodies, polyclonal, pab, western blotting, wb, sample |
Molecular weight | 60 kDa |
GenBank accession number | NP_068780 |
RRID | AB_2793717 |
Purification Method | Affinity Purified |
Buffer | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
Storage | Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage. |
Background Information
TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor)) is a transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.