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TBK1 antibody (mAb) (Clone 108A429)

Host / Isotype

Mouse / IgG1

Reactivity

Human, Mouse, Rat

Applications

WB

CloneNo.

108A429

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Cat No : 40909 40909

Synonyms

TBK1, TBK-1, TBK 1, mAb, monoclonal, antibody, antibodies

Validation Data Gallery

  • TBK1 mAb tested by Western blot. TBK1 detection by Western blot. The analysis of TBK1 was performed using TBK1 mAb at a 2 ug/ml dilution and nuclear extract from 293 cells (lane 1) and nuclear extract from 293 cells that had been transfected with human TBK1 cDNA (lane 2).

    TBK1 mAb tested by Western blot. TBK1 detection by Western blot. The analysis of TBK1 was performed using TBK1 mAb at a 2 ug/ml dilution and nuclear extract from 293 cells (lane 1) and nuclear extract from 293 cells that had been transfected with human TBK1 cDNA (lane 2).

Product Information

Tested Applications WB

Applications Validated by Active Motif: WB: 1 - 2 ug/ml dilution For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all blocking solutions may also reduce background. Individual optimization may be required.
Tested Reactivity Human, Mouse, Rat
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen This TBK1 antibody was raised against a peptide corresponding to amino acid residues 563-577 of human TBK1.
Full Name TBK1 antibody (mAb) (Clone 108A429)
Synonyms TBK1, TBK-1, TBK 1, mAb, monoclonal, antibody, antibodies
Molecular weight 80 kDa
GenBank accession numberNP_037386
RRIDAB_2793432
Purification Method Affinity Purified
Buffer PBS containing 0.02% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Background Information

TBK1 – TANK-binding kinase 1 is a regulator of the NFkB (NFkB p50 & NFkB p65) signaling pathway. NFkB signaling is controlled to a large extent by the sequestration of the NFkB complex in the cytoplasm by its association with one of the IkB family of proteins. IkB is phosphorylated by the IkB Kinase (IKK) complex, resulting in the degradation of IkB and the nuclear translocation of NFkB. TANK is an IkB family member that is specifically recognized and phosphorylated by TBK1, leading to the destruction of TANK and the activation of the NFkB pathway.