Sox2 antibody (pAb)
Host / Isotype
Rabbit / Serum
Reactivity
Mouse
Applications
ICC, IF, IHC, WB
Cat No : 39823,39824 39823
Synonyms
Validation Data Gallery
Product Information
| Tested Applications |
ICC, IF, IHC, WB
Applications Validated by Active Motif: WB: 1:2,000 - 1:10,000 dilution |
| Tested Reactivity | Mouse |
| Host / Isotype | Rabbit / Serum |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | This Sox2 antibody was raised against a peptide corresponding to amino acids amino acids 111-140 mouse Sox2. |
| Full Name | Sox2 antibody (pAb) |
| Synonyms | Sox2, SRY related HMG BOX gene 2, sox, sox 2, sox-2, embryogenesis, embryonic stem cell pluripotency, es cell, esc, Induced Pluripotency, microphthalmia, sample, stem cell, stem cells, chiphsabs |
| Molecular weight | 35 kDa |
| GenBank accession number | NP_035573 |
| RRID | AB_2793356 |
| Purification Method | None |
| Buffer | Rabbit serum containing 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| Storage | Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage. |
Background Information
Sox2 (SRY related HMG BOX gene 2) is a DNA binding transcription factor and a member of the SOX family of proteins. SOX proteins have an HMG box that binds DNA. Sox2 forms a complex with Oct-4 and controls the expression of a number of genes involved in embryonic. Sox2 is critical for early embryogenesis and for embryonic stem cell pluripotency and thus can serve as a stem cell marker. Overexpression of Sox2 (along with Oct-4, KLF4 and c-Myc) can transform mouse fibroblasts into a state resembling embryonic stem cells (ES cells), referred to as Induced Pluripotency. Defects in Sox2 are the cause of microphthalmia syndromic type 3.