SMRT / NCoR2 antibody (mAb) (Clone 5.10)
Host / Isotype
Mouse / IgG1
Reactivity
Human
Applications
WB
CloneNo.
5.10
Cat No : 61105,61106 61105
Synonyms
Validation Data Gallery
Product Information
| Tested Applications | WB |
| Tested Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | This SMRT / NCoR2 antibody was raised against a recombinant protein corresponding to amino acids 2004-2310 of human SMRT / NCoR2. |
| Full Name | SMRT / NCoR2 antibody (mAb) (Clone 5.10) |
| Synonyms | SMRT, NCOr2, Nuclear receptor corepressor 2, CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, Thyroid and retinoic-acid-receptor-associated corepressor, TRAC, transcriptional corepressor for nuclear receptors, immune response, mediating DNA repair, neuronal differentiation, cardiac development, large corepressor complex, SIN3A/B, histone deacetylases, HDAC1 and HDAC2, TBL1, TBLR1, GPS2, clone 5.10, sample, monoclonal |
| Molecular weight | 300 kDa |
| GenBank accession number | NP_006303 |
| RRID | AB_2615017 |
| Purification Method | Protein G Chromatography |
| Buffer | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| Storage | Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage. |
Background Information
SMRT / NCoR2 (Nuclear receptor corepressor 2, CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, Thyroid and retinoic-acid-receptor-associated corepressor, TRAC) is a transcriptional corepressor for nuclear receptors. SMRT / NCoR2 has been shown to play a role in regulating immune response, mediating DNA repair, and in neuronal differentiation and cardiac development. SMRT / NCoR2 is part of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. It also includes TBL1, TBLR1, and GPS2 that help stabilize the overall structure of the complex. SMRT / NCoR2 mediates the transcriptional repression activity of nuclear receptors by promoting histone deacetylation and chromatin condensation, thus preventing access of the basal transcription machinery.