• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

SATB2 antibody (pAb)

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

WB

Activ Motif logo

Cat No : 61575,61576 61575

Synonyms

SATB2, SATB Homeobox 2, SATB Family Member 2, Special AT-Rich Sequence-Binding Protein 2, KIAA1034, DNA-Binding Protein SATB2, DNA binding, trancription, chromatin remodeling, corepressor, repressor, polyclonal, pab, antibody, antibodies, western blotting, wb, sample

Validation Data Gallery

  • SATB2 antibody (pAb) tested by Western blot. SATB2 antibody detection by Western blot. The analysis was performed using 20 ug Saos-2 nuclear extract and SATB2 antibody at a 1:500 dilution.

    SATB2 antibody (pAb) tested by Western blot. SATB2 antibody detection by Western blot. The analysis was performed using 20 ug Saos-2 nuclear extract and SATB2 antibody at a 1:500 dilution.

Product Information

Tested Applications WB

Applications Validated by Active Motif: WB: 1:500 - 1:2,000 dilution The addition of 0.05% Tween 20 in the blocking buffer and primary antibody incubation buffer is recommended to aid in detection by Western blot. Individual optimization may be required.
Tested Reactivity Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen This antibody was raised against a peptide within the C-terminal region of human SATB2.
Full Name SATB2 antibody (pAb)
Synonyms SATB2, SATB Homeobox 2, SATB Family Member 2, Special AT-Rich Sequence-Binding Protein 2, KIAA1034, DNA-Binding Protein SATB2, DNA binding, trancription, chromatin remodeling, corepressor, repressor, polyclonal, pab, antibody, antibodies, western blotting, wb, sample
Molecular weight 90 kDa
GenBank accession numberNP_056080
RRIDAB_2793683
Purification Method Affinity Purified
Buffer Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Background Information

SATB2 (SATB homeobox 2; Special AT-Rich Sequence-Binding Protein 2) binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.