PARP-1 N-terminal antibody (pAb)
Host / Isotype
Rabbit / Serum
Reactivity
Human, Mouse
Applications
ChIP, WB
Cat No : 39061,39559,39560 39559
Synonyms
Validation Data Gallery
Product Information
Tested Applications |
ChIP, WB
Applications Validated by Active Motif: ChIP: 8 ul per ChIP WB: 1:5,000 - 1:50,000 dilution |
Tested Reactivity | Human, Mouse |
Host / Isotype | Rabbit / Serum |
Class | Polyclonal |
Type | Antibody |
Immunogen | This PARP-1 N-terminal antibody was raised against a His-Tagged fusion protein corresponding to the N-terminal half of human PARP-1 was used to generate this PARP-1 antibody. |
Full Name | PARP-1 N-terminal antibody (pAb) |
Synonyms | parp, parp1, DNA damage, ribosylation, adp-ribosylation, apoptosis, pAb, polyclonal, ADPRT, poly ADP-ribosyl transferase, antibody, antibodies, sample |
Molecular weight | 120 kDa |
GenBank accession number | NP_001609 |
RRID | AB_2793257 |
Purification Method | None |
Buffer | Rabbit serum containing 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. For your convenience, an IgG version (Catalog No. 61639) of this antibody that was purified by Protein A Chromatography is also available. |
Storage | Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage. |
Background Information
PARP-1 N-terminal (ADPRT) encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation and tumor transformation. It also plays a role in the regulation of the molecular events involved in the recovery of cells from DNA damage. Cleavage of PARP-1 (ADPRT) occurs following caspase activation during apoptosis. For additional information on PARP-1, please see the review article PARP-1: An Abundant and Ubiquitous Protein with Roles in Many Cellular Processes in the Targets & Applications section or our website.