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  • Overview
  • Product Information

KLF4 antibody (pAb)

Host / Isotype

Rabbit / IgG

Reactivity

Human, Wide Range Predicted

Applications

WB

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Cat No : 39745,39746 39745

Synonyms

KLF4, Kruppel-like factor 4, Kruppel-like factor 4, Kruppel, transcription factor, tf, zinc-finger, zn-finger, zn finger, KLF, gastrointestinal, skin, epithelial, development, proliferation, differentiation, oncogene, tumor suppressor, apoptosis, activator, repressor, embryonic stem cells, ESC, referred to as Induced Pluripotency, iPS, antibody, polyclonal, pAb, sample, dbdabs

Validation Data Gallery

  • KLF4 antibody tested by Western blot. Lane 1: Nuclear extract (20 ug) of Hct116 cells. Lane 2: Nuclear extract (20 ug) of primary human keratinocyte cells. Both probed with KLF4 antibody at a 1:5,000 dilution.

    KLF4 antibody tested by Western blot. Lane 1: Nuclear extract (20 ug) of Hct116 cells. Lane 2: Nuclear extract (20 ug) of primary human keratinocyte cells. Both probed with KLF4 antibody at a 1:5,000 dilution.

Product Information

Tested Applications WB

Applications Validated by Active Motif: WB: 1:2,000 - 1:5,000 dilution
Tested Reactivity Human, Wide Range Predicted
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen This KLF4 antibody was raised against recombinant full-length human KLF4.
Full Name KLF4 antibody (pAb)
Synonyms KLF4, Kruppel-like factor 4, Kruppel-like factor 4, Kruppel, transcription factor, tf, zinc-finger, zn-finger, zn finger, KLF, gastrointestinal, skin, epithelial, development, proliferation, differentiation, oncogene, tumor suppressor, apoptosis, activator, repressor, embryonic stem cells, ESC, referred to as Induced Pluripotency, iPS, antibody, polyclonal, pAb, sample, dbdabs
Molecular weight 55 kDa
GenBank accession numberNP_004226
RRIDAB_2614947
Purification Method Affinity Purified
Buffer Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Background Information

KLF4 (Kruppel-like factor 4) is a transcription factor that binds GC-rich DNA sequences having a consensus core DNA binding sequence of CACCC. It is a member of the Kruppel-like factor (KLF) family, highly expressed in the gastrointestinal tract, skin and other epithelial tissues. Krüppel-like factors are a family of zinc-finger transcription factors that play important roles in many fundamental biologic processes including development, proliferation, differentiation, and apoptosis. KLF4 can function both as an activator and repressor of transcription, depending on the gene targeted. Generally, KLF4 serves as a cell cycle regulator, and it may be a tumor suppressor. KLF4 also appears to function as an oncogene in some situations. Additionally, overexpression of KLF4 (along with Oct3/4, Sox2 and c-Myc) can transform mouse fibroblasts into a state resembling embryonic stem cells (ES cells), referred to as Induced Pluripotency.