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JMJD3 / KDM6B antibody (mAb) (Clone 67-A2)

Host / Isotype

Mouse / IgG1

Reactivity

Human, Mouse

Applications

WB

CloneNo.

67-A2

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Cat No : 61387,61388 61387

Synonyms

JMJD3 / KDM6B, JMJD3, KMD6B, lysine (K)-specific demethylase 6B, Lysine demethylase 6B, JMJD3, jumonji domain containing 3, lysine-specific demethylase 6B, jumonji domain containing 3, histone lysine demethylase, JmjC domain-containing protein 3, Jumonji domain-containing protein 3, antibody, monoclonal, mAb, western blotting, wb, sample

Validation Data Gallery

  • JMJD3/ KDM6B antibody (mAb) (Clone 67-A2) tested by Western blot. JMJD3/ KDM6B detection by Western blot. The analysis was performed using cell lysate from BJ cells (lane 1) and BJ cells irradiated (lane 2).

    JMJD3/ KDM6B antibody (mAb) (Clone 67-A2) tested by Western blot. JMJD3/ KDM6B detection by Western blot. The analysis was performed using cell lysate from BJ cells (lane 1) and BJ cells irradiated (lane 2).

Product Information

Tested Applications WB

Applications Validated by Active Motif: WB: 0.5 - 2 ug/ml dilution
Tested Reactivity Human, Mouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen This antibody was raised against a recombinant protein corresponding to amino acids 1028-1684 of human JMJD3 / KDM6B.
Full Name JMJD3 / KDM6B antibody (mAb) (Clone 67-A2)
Synonyms JMJD3 / KDM6B, JMJD3, KMD6B, lysine (K)-specific demethylase 6B, Lysine demethylase 6B, JMJD3, jumonji domain containing 3, lysine-specific demethylase 6B, jumonji domain containing 3, histone lysine demethylase, JmjC domain-containing protein 3, Jumonji domain-containing protein 3, antibody, monoclonal, mAb, western blotting, wb, sample
Molecular weight 150 kDa
GenBank accession numberNP_001073893
RRIDAB_2793615
Purification Method Protein A Chromatography
Buffer Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Background Information

JMJD3 / KMD6B (Jumonji domain-containing protein 3 lysine (K)-specific demethylase 6B) Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.