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Histone H1 antibody (pAb)

Host / Isotype

Rabbit / IgG

Reactivity

Human, Wide Range Predicted

Applications

WB

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Cat No : 61201,61202 61201

Synonyms

histone H1, H1, linker histone, pAb, polyclonal, antibody, antibodies, sample

Validation Data Gallery

  • Histone H1 antibody (pAb) tested by Western blot. Detection of Histone H1 by Western blot. The analysis was performed using HeLa nuclear extract (20 ug) and Histone H1 pAb at 1 ug/ml.

    Histone H1 antibody (pAb) tested by Western blot. Detection of Histone H1 by Western blot. The analysis was performed using HeLa nuclear extract (20 ug) and Histone H1 pAb at 1 ug/ml.

Product Information

Tested Applications WB

Applications Validated by Active Motif: WB: 0.5 - 2 ug/ml dilution
Tested Reactivity Human, Wide Range Predicted
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen This Histone H1antibody was raised against purified calf thymus Histone H1.
Full Name Histone H1 antibody (pAb)
Synonyms histone H1, H1, linker histone, pAb, polyclonal, antibody, antibodies, sample
Molecular weight 31 kDa
GenBank accession numberXP_010816821
RRIDAB_2636962
Purification Method Protein A Chromatography
Buffer Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. For your convenience, an unpurified serum version (Catalog No. 39707) of this antibody is also available.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Background Information

The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points; it is responsible for establishing higher-order chromatin structure. Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; they play a major role in regulating gene expression.