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FOXL2 antibody (pAb)

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

WB

Activ Motif logo

Cat No : 61283,61284 61283

Synonyms

FOXL2, forkhead box L2, forkhead transcription factor FOXL2, BPES, PFRK, POF3, BPES1, PINTO, antibody, polyclonal, pAb, sample

Validation Data Gallery

  • FOXL2 antibody (pAb) tested by Western blot. Detection of FOXL2 by Western blot analysis. Nuclear extract of OVCAR-3 cells (30 ug) was probed with FOXL2 pAb at a 1:500 dilution.

    FOXL2 antibody (pAb) tested by Western blot. Detection of FOXL2 by Western blot analysis. Nuclear extract of OVCAR-3 cells (30 ug) was probed with FOXL2 pAb at a 1:500 dilution.

Product Information

Tested Applications WB

Applications Validated by Active Motif: WB: 1:500 - 1:1,000 dilution
Tested Reactivity Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen This FOXL2 antibody was raised against a peptide within the N-terminal region of human FOXL2.
Full Name FOXL2 antibody (pAb)
Synonyms FOXL2, forkhead box L2, forkhead transcription factor FOXL2, BPES, PFRK, POF3, BPES1, PINTO, antibody, polyclonal, pAb, sample
Molecular weight 40 kDa
GenBank accession numberNP_075555
RRIDAB_2615047
Purification Method Affinity Purified
Buffer Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Background Information

FOXL2 (forkhead box L2, BPES, PFRK, POF3, BPES1, PINTO) is a transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.