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Bcl3 antibody (pAb)

Host / Isotype

Rabbit / Serum

Reactivity

Human

Applications

WB

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Cat No : 39761,39762 39761

Synonyms

bcl3, bcl-3, bcl 3, b-cell lymphoma 3 protein, oncogene, nfkb, nfkb p50, ikb, polyclonal, antibody, antibodies, sample, dbdabs

Validation Data Gallery

  • Bcl3 antibody tested by Western blot. Detection of Bcl3 by Western blot analysis. Lane 1: HeLa whole-cell extract (20 ug). Lane 2: Nuclear extract (20 ug) of Raji cells. Both probed with Bcl3 antibody at a dilution of 1:1,000.

    Bcl3 antibody tested by Western blot. Detection of Bcl3 by Western blot analysis. Lane 1: HeLa whole-cell extract (20 ug). Lane 2: Nuclear extract (20 ug) of Raji cells. Both probed with Bcl3 antibody at a dilution of 1:1,000.

Product Information

Tested Applications WB

Applications Validated by Active Motif: WB: 1:500 - 1:2,000 dilution
Tested Reactivity Human
Host / Isotype Rabbit / Serum
Class Polyclonal
Type Antibody
Immunogen This Bcl3 antibody was raised against a peptide within the C-terminal half of human Bcl3.
Full Name Bcl3 antibody (pAb)
Synonyms bcl3, bcl-3, bcl 3, b-cell lymphoma 3 protein, oncogene, nfkb, nfkb p50, ikb, polyclonal, antibody, antibodies, sample, dbdabs
Molecular weight 60 kDa
GenBank accession numberNP_005169
RRIDAB_2793333
Purification Method None
Buffer Rabbit serum containing 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Background Information

Bcl3 (B-cell lymphoma 3 protein) functions as a transcriptional co-activator that activates through its association with NFkB homodimers. Bcl3 contains seven ankyrin repeats, which are most closely related to those found in IkB proteins. Bcl3 also functions as a form of IkBNFkB p50 subunit inhibiting its translocation to the nucleus. The expression of this gene can be induced by NFkB, which forms a part of the autoregulatory loop that controls the nuclear residence of NFkB p50. Bcl3 is overexpressed in a number of cancers, can transform fibroblasts and induce tumors in nude mice, thus implicating Bcl3 as a proto-oncogene.