LAIR1 Monoklonaler Antikörper

LAIR1 Monoklonal Antikörper für IF

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

IF

Konjugation

CoraLite®594 Fluorescent Dye

CloneNo.

1A5D1

Kat-Nr. : CL594-67220

Synonyme

CD305, hLAIR1, LAIR 1, LAIR1

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Galerie der Validierungsdaten

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  IF Staining of human tonsillitis using CL594-67220

  Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using CoraLite®594 LAIR1 antibody (CL594-67220, Clone: 1A5D1 ) at dilution of 1:200.

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  IF Staining of human tonsillitis using CL594-67220

  Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using CoraLite®594 LAIR1 antibody (CL594-67220, Clone: 1A5D1 ) at dilution of 1:200.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IF: humanes Tonsillitisgewebe

Empfohlene Verdünnung

• Immunfluoreszenz (IF): IF : 1:50-1:500

Sample-dependent, check data in validation data gallery

Produktinformation

CL594-67220 bindet in IF LAIR1 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: LAIR1 fusion protein Ag14459
• Vollständiger Name: leukocyte-associated immunoglobulin-like receptor 1
• Berechnetes Molekulargewicht: 287 aa, 31 kDa
• GenBank-Zugangsnummer: BC027899
• Gene symbol: LAIR1
• Gene ID (NCBI): 3903
• Konjugation: CoraLite®594 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 588 nm / 604 nm
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: BS mit 50% Glyzerin, 0,05% Proclin300, 0,5% BSA, pH 7,3.
• Lagerungsbedingungen: Bei -20°C lagern. Vor Licht schützen. Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs (PMID: 9285412). LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes (PMID: 10229813). It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor (PMID: 16754721). Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1 (PMID: 21955987).