CD279 (PD-1) Monoklonaler Antikörper

CD279 (PD-1) Monoklonal Antikörper für FC

Wirt / Isotyp

Armenian Hamster / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

PE Fluorescent Dye

CloneNo.

J43.1

Kat-Nr. : PE-65120

Synonyme

CD279, Ly101, PD 1, PD-1, Pdc1, Pdcd1, programmed cell death 1



Geprüfte Anwendungen

Erfolgreiche Detektion in FCanti-CD3/CD28-stimulated mouse splenocytes

Empfohlene Verdünnung

AnwendungVerdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

PE-65120 bindet in FC CD279 (PD-1) und zeigt Reaktivität mit Maus

Getestete Reaktivität Maus
Wirt / Isotyp Armenian Hamster / IgG
Klonalität Monoklonal
Typ Antikörper
Immunogen k.A.
Vollständiger Name programmed cell death 1
GenBank-ZugangsnummerBC119179
Gene symbol Pdcd1
Gene ID (NCBI) 18566
Konjugation PE Fluorescent Dye
Excitation/Emission maxima wavelengths496 nm, 565 nm / 578 nm
Form Liquid
Reinigungsmethode Affinitätsreinigung
Lagerungspuffer PBS with 0.1% sodium azide and 0.5% BSA.
LagerungsbedingungenStore at 2-8°C. Avoid exposure to light. Stable for one year after shipment. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820). Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218). It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436).

Protokolle

Produktspezifische Protokolle
FC protocol for PE CD279 (PD-1) antibody PE-65120Protokoll herunterladen
Standard-Protokolle
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