SOSTDC1 Polyclonal antibody

SOSTDC1 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 22213-1-AP

Synonyms

CDA019, Ectodermal BMP inhibitor, ECTODIN, sclerostin domain containing 1, SOSTDC1, USAG 1, USAG1

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Validation Data Gallery

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  WB analysis using 22213-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 22213-1-AP (SOSTDC1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: human milk

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

22213-1-AP targets SOSTDC1 in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: SOSTDC1 fusion protein Ag17538
• Full Name: sclerostin domain containing 1
• Calculated Molecular Weight: 206 aa, 23 kDa
• Observed Molecular Weight: 23-26 kDa
• GenBank Accession Number: BC008484
• Gene Symbol: SOSTDC1
• Gene ID (NCBI): 25928
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

SOSTDC1 (Sclerostin domain-containing protein 1), also known as Ectodin (Ectodermal BMP inhibitor), is a member of the sclerostin family. It is an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain and is highly abundant in milk and kidney. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.