MEN1 Monoclonal antibody

MEN1 Monoclonal Antibody for WB, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

3A6A11

Cat no : 68473-1-Ig

Synonyms

MEAI, MEN1, Menin, multiple endocrine neoplasia I, SCG2

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Validation Data Gallery

• 

  WB analysis using 68473-1-Ig

  Various lysates were subjected to SDS PAGE followed by western blot with 68473-1-Ig (MEN1 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: HepG2 cells, HEK-293 cells, HeLa cells, U2OS cells, LNCaP cells, K-562 cells, Jurkat cells

Recommended dilution

• Western Blot (WB): WB : 1:5000-1:50000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

68473-1-Ig targets MEN1 in WB, ELISA applications and shows reactivity with Human samples.

• Tested Reactivity: Human
• Host / Isotype: Mouse / IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen: MEN1 fusion protein Ag7566
• Full Name: multiple endocrine neoplasia I
• Calculated Molecular Weight: 68 kDa
• Observed Molecular Weight: 68-70 kDa
• GenBank Accession Number: BC002544
• Gene Symbol: MEN1
• Gene ID (NCBI): 4221
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein G purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

MEN1, also named as Menin or MEAI, is a tumor suppressor protein encoded by the MEN1 gene. It is located in nucleus and ubiquitous expression in spleen and lymph node. The calculated molecular weight of MEN1 is 68 kDa. Its inactivation has been implicated in tumors of many endocrine tissues. Germline inactivating mutations of MEN1 gene are the main cause of multiple endocrine neoplasia type 1 (MEN1), a syndrome characterized by tumors in the pituitary gland, the parathyroid glands, and the enteropancreatic neuroendocrine tissues. Recent study shows astroglia menin deficiency leads to depressive-like behaviors in mice.