GPR39 Polyclonal antibody

GPR39 Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (1)

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

Publications

1

Cat no : 23326-1-AP

Synonyms

G protein coupled receptor 39, GPR39

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Validation Data Gallery

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  IHC staining of human small intestine using 23326-1-AP

  Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 23326-1-AP (GPR39 Antibody) at dilution of 1:200 (under 10x lens).

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  IHC staining of human small intestine using 23326-1-AP

  Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 23326-1-AP (GPR39 Antibody) at dilution of 1:200 (under 40x lens).

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Tested Applications

• Positive IHC detected in: human small intestine tissue; Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

• Immunohistochemistry (IHC): IHC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• WB: See 1 publications below

Product Information

23326-1-AP targets GPR39 in WB, IHC, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Cited Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: GPR39 fusion protein Ag19913
• Full Name: G protein-coupled receptor 39
• Calculated Molecular Weight: 453 aa, 51 kDa
• GenBank Accession Number: BC125046
• Gene Symbol: GPR39
• Gene ID (NCBI): 2863
• RRID: AB_2879255
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

GPR39 (G protein-coupled receptor 39), a member of the ghrelin family of G protein-coupled receptors, is zinc-responsive and contributes to the regulation of diverse neurovascular and neurologic functions (PMID: 34360964). GPR39 has relatively high ligand-independent constitutive activity, based on an aromatic cluster on the inner face of the extracellular ends of TM domains VI and VII, similar to other members of the ghrelin receptor family (PMID: 33918078).

Publications

Species	Application	Title
mouse	WB	Int J Biochem Cell Biol; The mechanism underlying the TC-G 1008 rescue of reactive oxygen species (ROS)-induced osteoblast apoptosis by the upregulation of peroxiredoxin 1; Authors - Panpan Yang