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  • KD/KO Validated

FUNDC1 Polyclonal antibody

FUNDC1 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

Human, mouse, rat and More (1)

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 28519-1-AP

Synonyms

FUN14 domain containing 1, FUNDC1



Tested Applications

Positive WB detected inRAW 264.7 cells, RAW 264, .7 cells, mouse brain tissue, mouse liver tissue, rat brain tissue, rat liver tissue, C6 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:5000-1:20000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

28519-1-AP targets FUNDC1 in WB, ELISA applications and shows reactivity with Human, mouse, rat samples.

Tested Reactivity Human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen FUNDC1 fusion protein Ag29358
Full Name FUN14 domain containing 1
Calculated Molecular Weight 155 aa, 17 kDa
Observed Molecular Weight17 kDa
GenBank Accession NumberBC042813
Gene Symbol FUNDC1
Gene ID (NCBI) 139341
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

FUNDC1 is a novel mitochondrial-associated membrane (MAM) protein, enriched at the MAM by interacting with the ER resident protein CANX (calnexin) under hypoxia. As mitophagy proceeds, it dissociates from CANX and preferably recruits DNM1L/DRP1 to drive mitochondrial fission in response to hypoxic stress.

Protocols

Product Specific Protocols
WB protocol for FUNDC1 antibody 28519-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

Clin Sci (Lond)

Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning

Authors - Limin Shi
  • KD Validated
humanWB

Redox Biol

VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats

Authors - Hong Chen