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MALT1 Polyclonal antibody

MALT1 Polyclonal Antibody for WB, IHC, IF/ICC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF/ICC, IP, CoIP, ELISA

Conjugate

Unconjugated

Cat no : 11660-1-AP

Synonyms

Mucosa-associated lymphoid tissue lymphoma translocation protein 1, MLT1, MLT, MALT lymphoma-associated translocation, MALT 1



Tested Applications

Positive WB detected inHeLa cells, HEK-293 cells, mouse testis tissue
Positive IHC detected inhuman lymphoma tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF/ICC detected inHepG2 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
Immunohistochemistry (IHC)IHC : 1:20-1:200
Immunofluorescence (IF)/ICCIF/ICC : 1:10-1:100
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

11660-1-AP targets MALT1 in WB, IHC, IF/ICC, IP, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen MALT1 fusion protein Ag2182
Full Name mucosa associated lymphoid tissue lymphoma translocation gene 1
Calculated Molecular Weight 824 aa, 92 kDa
Observed Molecular Weight 92-100 kDa
GenBank Accession NumberBC030143
Gene Symbol MALT1
Gene ID (NCBI) 10892
RRIDAB_2139135
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 belongs to caspase-like protein superfamily.MALT1 plays a potential role in the regulation of apoptosis and induces NFKB activation and required for the normal development of B cells and for the activation of the IKK complex.It acts as a caspase and mediates additional functions related to T cell activation, cleaving both the ubiquitin editing enzyme,TNFAIP3,and the C terminus of BCL10 .It has two isoforms.Researches showed that inhibition of MALT1 blocks A20 and BCL10 cleavage, reduces NFKB activity, and decreases the expression of NFKB targets BCLXL.

Protocols

Product Specific Protocols
WB protocol for MALT1 antibody 11660-1-APDownload protocol
IHC protocol for MALT1 antibody 11660-1-APDownload protocol
IF protocol for MALT1 antibody 11660-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
ratWB

Eur J Pharmacol

Inhibition of MALT1 reduces ferroptosis in rat hearts following ischemia/reperfusion via enhancing the Nrf2/SLC7A11 pathway

Authors - Ya-Qian Jiang
human,mouseWB

ACS Chem Neurosci

Telaprevir Improves Memory and Cognition in Mice Suffering Ischemic Stroke via Targeting MALT1-Mediated Calcium Overload and Necroptosis

Authors - Yi-Yue Zhang
humanIHC

Biomedicines

Mucosa-Associated Lymphoid Tissue 1 Is an Oncogene Inducing Cell Proliferation, Invasion, and Tumor Growth via the Upregulation of NF-κB Activity in Human Prostate Carcinoma Cells.

Authors - Ke-Hung Tsui
ratIHC

Food Funct

Allicin suppressed Escherichia coli-induced urinary tract infections by a novel MALT1/NF-κB pathway.

Authors - Zhenglin Chang
mouse,ratWB

Arch Biochem Biophys

MALT1 promotes necroptosis in stroke rat brain via targeting the A20/RIPK3 pathway

Authors - Zi-Mei Peng
ratWB,IF,CoIP

Mol Neurobiol

The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination

Authors - Yi-Yue Zhang
  • KD Validated