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CoraLite® Plus 488-conjugated MTMR2 Monoclonal antibody
MTMR2 Monoclonal Antibody for
Host / Isotype
Mouse / IgG2b
Reactivity
Human
Applications
Conjugate
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
1B11B7
Cat no : CL488-67312
Synonyms
Validation Data Gallery
Product Information
CL488-67312 targets MTMR2 in applications and shows reactivity with Human samples.
| Tested Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | MTMR2 fusion protein Ag28413 |
| Full Name | myotubularin related protein 2 |
| Calculated Molecular Weight | 73 kDa |
| Observed Molecular Weight | 66-73 kDa |
| GenBank Accession Number | BC052990 |
| Gene Symbol | MTMR2 |
| Gene ID (NCBI) | 8898 |
| Conjugate | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Purification Method | Protein A purification |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
MTMR2(myotubularin-related protein 2) is also named as KIAA1073 and belongs to the non-receptor class myotubularin subfamily, which is characterized by the presence of a phosphatase domain. It may regulate vesicular trafficking in Schwann cells (PMID:17880751) and its reversible phosphorylation represents a critical mechanism for regulating the subcellular localization of MTMR2(PMID:21372139). MTMR2 is a 73 kDa protein in its monomeric form and exist as a dimer within cells and the protein re-localizes to membranes in hypo-osmotic settings(PMID:16399794). Defects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1). MTMR2 has two isofroms with the molecular mass of 73 and 66 kDa.
