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Zunair Khokhar, research scientist at the University of Virginia, discusses the role of SAS1B in Tumor Progression. This webinar is dedicated to the memory of Dr. John Herr.
A key challenge in oncology drug development is finding a target that is essential for tumorigenesis yet is unique to the tumor to mitigate deleterious side-effects. This is quite rare, but Zunair discusses how SAS1B may be one of these ideal targets. This protein is involved in folliculogenesis, so it is not expressed in other cell types in the body, and data suggest that targeting this protein inhibits tumorigenesis. Listen to Zunair’s webinar to learn more about the science behind this protein.
SAS1B is a membrane protein involved in female egg production and its expression is restricted to multiple tumor types in adults.
Targeting SAS1B with an antibody-drug conjugate kills several different cell lines.
Knocking in this gene into non-cancerous cell line MCF10A5E increases migration in invasion assay and proliferation
Though these data are promising, more work needs to be done to uncover the mechanism driving cancer.
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