Notable Publications

December 2016 – January 2017

What matters to Proteintech is the success of its antibodies in the hands of scientists. In the month of December alone there were over 530 publications citing Proteintech antibodies worldwide. Here’s just a small selection of publications from between December 2016 and the beginning of 2017.

Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia

Nature Genetics (2016)

Institution:  Molecular Neurosciences, Developmental Neurosciences, UCL Institute of Child Health

Country: UK

Cited Product: THAP1 Rabbit PolyAb

Product Focus: THAP1 Antibody
KD/KO Validated
Catalog number: 12584-1-AP
Type: Rabbit polyclonal
Applications: ELISA, WB, IHC
Publications 7

Abstract: 

Histone lysine methylation, mediated by mixed-lineage leukemia proteins, is now known to be critical in the regulation of gene expression, genomic stability, cell cycle and nuclear architecture. Despite MLL proteins being postulated as essential for normal development, little is known about the specific functions of the different MLL lysine methyltransferases. Here we report heterozygous variants in the gene KMT2B (also known as MLL4) in 27 unrelated individuals with a complex progressive childhood-onset dystonia, often associated with a typical facial appearance and characteristic brain magnetic resonance imaging findings. Continue reading...

Reference:  Meyer E, Carss KJ, Rankin J et al. Mutations in the Histone Methyltransferase Gene, KMT2B Cause Early Onset Dystonia. Nature Genetics; 19 Dec 2016

SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia

Nature Medicine (2016)

Institution: Institute of Medical Virology, University of Frankfurt

Country: Germany

Cited product: SAMHD1 Rabbit PolyAb

Product Focus: SAMHD1 Antibody
KD/KO Validated
Catalog number: 12586-1-AP
Type: Rabbit polyclonal
Applications: ELISA, WB, IP, IHC, IF, FC
Publications: 21

Reference: Schneider C, Oellerich T et al. SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia. Nature Medicine; 19 Dec 2016

LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency.

Nature Cell biology (2017)

Institution: Stem Cell Transplantation Program, Division of Hematology/Oncology, Manton Center for Orphan Disease Research, Boston Children's Hospital and Dana-Farber Cancer Institute

Country: USA

Cited products: NDUFB10 Rabbit PolyAb and RPL23 Rabbit PolyAb 

Product Focus: NDUFB10 Antibody
Catalog number: 15589-1-AP
Type: Rabbit polyclonal
Applications: ELISA, WB, IP, IHC
Publications: 4
Product Focus: RPL23 Antibody
Catalog number: 16086-1-AP
Type: Rabbit polyclonal
Applications: ELISA, WB, IHC
Publications: 3

Reference: : Tsanov K, Pearson D et al. LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency. Nature Cell Biology; 1 Jan 2017

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

Nature Cell biology (2017)

Institution: Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California

Country: USA

Cited product: Lamin B1 Rabbit PolyAb 

Product Focus: Lamin B1 Antibody
Catalog number: 12987-1-AP
Type: Rabbit polyclonal
Applications: ELISA, WB, IP, IHC, IF, FC, CHIP
Publications: 67

Reference: Ly P, Levi S et al. Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining. Nature Cell Biology; 1 Jan 2017

Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections

Nature Neuroscience (2017)

Institution: Neuronal Networks Group, German Center for Neurodegenerative Diseases

Country: Germany

Cited product: WFS1 Rabbit PolyAb

Product Focus: WFS1 Antibody
KD/KO Validated
Catalog number: 11558-1-AP
Type: Rabbit polyclonal
Applications: ELISA, WB, IP, IHC, IF, coIP
Publications: 20

Abstract:

The medial septum and diagonal band of Broca (MSDB) send glutamatergic axons to medial entorhinal cortex (MEC). We found that this pathway provides speed-correlated input to several MEC cell-types in layer 2/3. The speed signal is integrated most effectively by pyramidal cells but also excites stellate cells and interneurons. Thus, the MSDB conveys speed information that can be used by MEC neurons for spatial representation of self-location.

Reference: Justus D, Dalügge D et al. Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections. Nature Neuroscience; 1 Jan 2017

Company News

Posted:
11 January, 2017

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