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All the posters in the Proteintech library are available in PDF format or can be requested as a hard copy.
GSK3 (Glycogen Synthase Kinase-3) is a signaling mediator involved in a variety of different signaling pathways including WNT, growth factors, insulin, and Hedgehog pathways.
Recent studies have shown GSK3 dysregulation to be associated with a number of diseases, including Type II diabetes, Alzheimer’s disease, inflammation, cancer, and bipolar disorder (D Wu and W Pan. 2010). It has also been suggested that inhibition of GSK has the capacity to undergo oxidative metabolism and has protective effects on neurons, counteracting ischemic neuronal death (Valerio et al., 2011).
|beta-Catenin||PI3K p110 (alpha)|
|eIF2A||PI3K p110 (beta)|
|ERK1/2||PI3K p110 (gamma)|
Valerio A et al. (2011). Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production.. J Neurochem. 116 (6), p1471-4159.