MPZL2 Polyklonaler Antikörper

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• KD/KO Validated

MPZL2 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IF, FC, IHC, ELISA

Konjugation

Unkonjugiert

Publikationen

7

Kat-Nr. : 11787-1-AP

Synonyme

Epithelial V like antigen 1, EVA, EVA1, MPZL2, myelin protein zero like 2

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Galerie der Validierungsdaten

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  WB analysis using 11787-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 11787-1-AP (MPZL2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: A431-Zellen, HaCaT-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 4 publications below
• IHC: See 2 publications below
• IF: See 2 publications below
• FC: See 1 publications below

Produktinformation

11787-1-AP bindet in WB, IF, FC, IHC, ELISA MPZL2 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: MPZL2 fusion protein Ag2419
• Vollständiger Name: myelin protein zero-like 2
• Berechnetes Molekulargewicht: 215 aa, 24 kDa
• Beobachtetes Molekulargewicht: 24-30 kDa
• GenBank-Zugangsnummer: BC017774
• Gene symbol: MPZL2
• Gene ID (NCBI): 10205
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

MPZL2 (myelin protein zero-like 2), also named as EVA (epithelial V-like antigen) or EVA1, is a type 1 transmembrane protein of the myelin P0 protein family, containing an Ig-like V-type (immunoglobulin-like) domain and two potential glycosylation sites. MPZL2 is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis.

Publikationen

Species	Application	Title
mouse	WB	Cell; Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.; Authors - Wu Jun J
mouse	IF	Am J Hum Genet; MPZL2, Encoding the Epithelial Junctional Protein Myelin Protein Zero-like 2, Is Essential for Hearing in Man and Mouse.; Authors - Mieke Wesdorp
human	WB	PLoS Pathog; Haploid Genetic Screens Identify an Essential Role for PLP2 in the Downregulation of Novel Plasma Membrane Targets by Viral E3 Ubiquitin Ligases.; Authors - Timms Richard T RT
human	WB,IHC	Cancer Sci; Epithelial V-like antigen 1 promotes hepatocellular carcinoma growth and metastasis via the ERBB-PI3K-AKT pathway.; Authors - QianZhi Ni ; KD Validated
mouse	WB,IF	Hum Genet; MPZL2 is a novel gene associated with autosomal recessive nonsyndromic moderate hearing loss.; Authors - Guney Bademci
mouse	FC	PLoS One; Epithelial V-like antigen mediates efficacy of anti-alpha₄ integrin treatment in a mouse model of multiple sclerosis.; Authors - Erik Wright