PCDHAC1 Polyclonal antibody

PCDHAC1 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 24314-1-AP

Synonyms

PCDH ALPHA C1, PCDHAC1, Protocadherin alpha C1

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Validation Data Gallery

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  WB analysis using 24314-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 24314-1-AP (PCDHAC1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: A549 cells, K-562 cells, SK-N-SH cells, SH-SY5Y cells, mouse brain tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

24314-1-AP targets PCDHAC1 in WB, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: PCDHAC1 fusion protein Ag19431
• Full Name: protocadherin alpha subfamily C, 1
• Calculated Molecular Weight: 818 aa, 88 kDa
• Observed Molecular Weight: ~110 kDa
• GenBank Accession Number: BC136774
• Gene Symbol: PCDHAC1
• Gene ID (NCBI): 56135
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Protocadherins, which constitute the largest subgroup within the cadherin superfamily, are predominantly expressed in the nervous system and are probably involved in the regulation of neuronal recognition and connectivity (PMID: 17936607; 12231349; 17133224). The protocadherin subfamily can be further subdivided into three groups: the clustered protocadherins, comprising α-, β- and γ-protocadherins; δ-protocadherins; and others, many of which are solitary (PMID: 17133224). PCDHAC1 belongs to the α-protocadherin (PCDHA) cluster. The differential expression of PCDHAC1 may be related to the influence of maternal cadmium on fetal growth (PMID: 27544570).