HLA-DMA Recombinant antibody
HLA-DMA Recombinant Antibody for FC, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
Human
Applications
FC, ELISA
Conjugate
Unconjugated
CloneNo.
230155D3
Cat no : 82899-1-RR
Synonyms
Validation Data Gallery
Tested Applications
Positive FC detected in | A431 cells |
Recommended dilution
Application | Dilution |
---|---|
Flow Cytometry (FC) | FC : 0.13 ug per 10^6 cells in a 100 µl suspension |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Product Information
82899-1-RR targets HLA-DMA in FC, ELISA applications and shows reactivity with Human samples.
Tested Reactivity | Human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | HLA-DMA fusion protein Ag2452 |
Full Name | major histocompatibility complex, class II, DM alpha |
Calculated Molecular Weight | 261 aa, 29 kDa |
GenBank Accession Number | BC026279 |
Gene Symbol | HLA-DMA |
Gene ID (NCBI) | 3108 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
Human major histocompatibility complex (MHC) antigens, also referred to as human leukocyte antigens (HLA), are encoded by genes located on the short arm of chromosome 6 (6p21.3). There are two classes of HLA antigens: class I (HLA-A, B and C) and class II (HLA-D). The class II molecules are composed of two non-covalently associated alpha and beta chains. HLA-DMA and HLA-DMB form a functional heterodimer that is critical in the pathway of class II antigen presentation. HLA-DM plays a critical role in catalyzing the release of Class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides.