• Featured Product
  • KD/KO Validated

GPR137 Polyclonal antibody

GPR137 Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IF, IHC, ELISA

Conjugate

Unconjugated

Cat no : 11929-1-AP

Synonyms

C11orf4, G protein coupled receptor 137, GPR137, GPR137A, TM7SF1L1



Tested Applications

Positive IHC detected inmouse brain tissue, human gliomas tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

11929-1-AP targets GPR137 in WB, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen GPR137 fusion protein Ag2611
Full Name G protein-coupled receptor 137
Calculated Molecular Weight 396 aa, 44 kDa
GenBank Accession NumberBC033920
Gene Symbol GPR137
Gene ID (NCBI) 56834
RRIDAB_10694423
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

G protein-coupled receptors (GPRs) are highly related to oncogenesis and cancer metastasis. G protein-coupled receptor 137 (GPR137) was initially reported as a novel orphan GPR about 10 years ago. GPR137 is ubiquitously expressed in the central nervous system (CNS), mainly in the hippocampus (PMID: 22025619). GPR137 is involved in the progression of human glioma, suggesting GPR137 as a potential oncogene of glioma cells (PMID: 24870220). Recent study shows that GPR137 plays an important role in colon cancer cell proliferation (PMID: 25301753).

Protocols

Product Specific Protocols
IHC protocol for GPR137 antibody 11929-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Biotechnol Appl Biochem

Knockdown of GPR137 by RNAi inhibits pancreatic cancer cell growth and induces apoptosis.

Authors - Xianping Cui
humanWB, IF

Biotechnol Appl Biochem

G-protein-coupled receptor 137 accelerates proliferation of urinary bladder cancer cells in vitro.

Authors - Yiheng Du
  • KD Validated
humanWB

Cell Biol Int

Down-Regulation of G Protein-Coupled Receptor 137 by RNA Interference Inhibits Cell Growth of Two Hepatoma Cell Lines.

Authors - Xin Shao
humanIHC

Neurol Sci

Inhibition of GPR137 expression reduces the proliferation and colony formation of malignant glioma cells.

Authors - Gang Zong
humanWB

J Bone Oncol

Small interfering RNA-mediated silencing of G-protein-coupled receptor 137 inhibits growth of osteosarcoma cells.

Authors - Hao Li
humanWB

Mol Med Rep

RNA interference-mediated silencing of G protein-coupled receptor 137 inhibits human gastric cancer cell growth.

Authors - Zishu Wang
  • KD Validated