• Featured Product
  • KD/KO Validated

DYX1C1 Polyclonal antibody

DYX1C1 Polyclonal Antibody for WB, IP, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IP, IF, IHC, ELISA

Conjugate

Unconjugated

Cat no : 14522-1-AP

Synonyms

DYX1, DYX1C1, DYXC1, EKN1, RD



Tested Applications

Positive WB detected inrat testis tissue, mouse testis tissue
Positive IP detected inmouse testis tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:6000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

14522-1-AP targets DYX1C1 in WB, IP, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen DYX1C1 fusion protein Ag5997
Full Name dyslexia susceptibility 1 candidate 1
Calculated Molecular Weight 49 kDa
Observed Molecular Weight 48 kDa
GenBank Accession NumberBC062564
Gene Symbol DYX1C1
Gene ID (NCBI) 161582
RRIDAB_2093955
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

DYX1C1 initially was described as the first candidate gene for developmental dyslexia. The protein contains three TPR motifs and one p23 domain, all commonly known for their protein-protein interactions. It also has been linked to neuronal migration. Recently it has been reported that the expression of DYX1C1 protein is lost in breast cancer and patients who have lost DYX1C1 expression have a poor overall survival,indicating that DYX1C1 is a potential prognostic biomarker in breast cancer.

Protocols

Product Specific Protocols
WB protocol for DYX1C1 antibody 14522-1-APDownload protocol
IP protocol for DYX1C1 antibody 14522-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

Nat Genet

DYX1C1 is required for axonemal dynein assembly and ciliary motility.

Authors - Tarkar Aarti A
  • KO Validated
humanIF

Biol Psychiatry

Molecular networks of DYX1C1 gene show connection to neuronal migration genes and cytoskeletal proteins.

Authors - Kristiina Tammimies
humanWB,IF

Mol Endocrinol

The rs3743205 SNP is important for the regulation of the dyslexia candidate gene DYX1C1 by estrogen receptor β and DNA methylation.

Authors - Tammimies Kristiina K
humanIHC

BMC Cancer

The dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer.

Authors - Rosin Gustaf G
humanWB,IP

BMC Mol Cell Biol

Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2

Authors - Andrea Bieder