Activation Inhibition Indirectly activation Translocation Phosphorylation P m 6 A methylation mRNA splicing /Processing mRNA stabilization mRNA structure Degradation Translation Export / Alternative splicing Demethylation Nucleus Cytoplasm RNA RNA m 6 A mRNA WTAP METTL16 RBM15/15B HNRNPA2B1 IGF2BP1 IGF2BP2 IGF2BP3 YTHDF2 YTHDC1 YTHDF1 YTHDF3 EIF3 HNRNPC VIRMA CBLL1 METTL14 METTL3 FTO ALKBH5