hamartin Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 20988-1-AP

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Size: 09µ/gram

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Species specificity:
Human, Mouse, Rat

Positive WB detected in:
HeLa cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human kidney tissue, human skeletal muscle tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:200-1:2000
IP : 1:500-1:5000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.

Immunogen Information


Immunogen:
Peptide

Full name:
tuberous sclerosis 1

Calculated molecular weight:
130 kDa

Observed molecular weight:
70 kDa, 130-140 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TSC1

Synonyms
Hamartin, KIAA0243, LAM, TSC, TSC1, tuberous sclerosis 1, Tuberous sclerosis 1 protein
Background

TSC1, also named as KIAA0243 and TSC, is implicated as a tumor suppressor. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. In complex with TSC2, TSC1 inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. It seems not to be required for TSC2 GAP activity towards RHEB. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). The antibody is specific to TSC1. This antibody can recognize two isoforms: 70 kDa (667aa) and 130 kDa.


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