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ZNF750 Polyclonal antibody

ZNF750 Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

Cat no : 21752-1-AP

Synonyms

Protein ZNF750, Zfp750, zinc finger protein 750, ZNF750

Validation Data Gallery

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  • Immunohistochemistry (IHC) staining of human oesophagus cancer tissue using ZNF750 Polyclonal antibody (21752-1-AP)

    IHC staining of human oesophagus cancer using 21752-1-AP

    Immunohistochemical analysis of paraffin-embedded human oesophagus cancer tissue slide using 21752-1-AP (ZNF750 Antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of human oesophagus cancer tissue using ZNF750 Polyclonal antibody (21752-1-AP)

    IHC staining of human oesophagus cancer using 21752-1-AP

    Immunohistochemical analysis of paraffin-embedded human oesophagus cancer tissue slide using 21752-1-AP (ZNF750 Antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of human skin tissue using ZNF750 Polyclonal antibody (21752-1-AP)

    IHC staining of human skin using 21752-1-AP

    Immunohistochemical analysis of paraffin-embedded human skin tissue slide using 21752-1-AP (ZNF750 Antibody) at dilution of 1:200 (under 10x lens).

  • Immunohistochemistry (IHC) staining of human skin tissue using ZNF750 Polyclonal antibody (21752-1-AP)

    IHC staining of human skin using 21752-1-AP

    Immunohistochemical analysis of paraffin-embedded human skin tissue slide using 21752-1-AP (ZNF750 Antibody) at dilution of 1:200 (under 40x lens).

  • Immunohistochemistry (IHC) staining of human skin cancer tissue using ZNF750 Polyclonal antibody (21752-1-AP)

    IHC staining of human skin cancer using 21752-1-AP

    Immunohistochemical analysis of paraffin-embedded human skin cancer tissue slide using 21752-1-AP (ZNF750 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of human skin cancer tissue using ZNF750 Polyclonal antibody (21752-1-AP)

    IHC staining of human skin cancer using 21752-1-AP

    Immunohistochemical analysis of paraffin-embedded human skin cancer tissue slide using 21752-1-AP (ZNF750 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Tested Applications

Positive IHC detected inhuman oesophagus cancer tissue, human skin tissue, human skin cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

The immunogen of 21752-1-AP is ZNF750 Fusion Protein expressed in E. coli.

Tested Reactivity human, mouse
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen ZNF750 fusion protein Ag16116
Full Name zinc finger protein 750
Calculated Molecular Weight 723 aa, 77 kDa
Observed Molecular Weight 70-77 kDa
GenBank Accession NumberBC109037
Gene Symbol ZNF750
Gene ID (NCBI) 79755
RRIDAB_10863125
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

ZNF750 is a novel nuclear protein highly expressed in differentiated skin keratinocytes. Mutation of ZNF750 is linked with familial psoriasis. Recently ZNF was found to be significantly mutated in esophageal squamous cell carcinoma (ESCC). Expression of ZNF750 is decreased in ESCC compared to the normal tissue.

Protocols

Product Specific Protocols
IHC protocol for ZNF750 antibody 21752-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanIHC

Int J Cancer

Identification of calmodulin-like protein 5 as tumor-suppressor gene silenced during early stage of carcinogenesis in squamous cell carcinoma of uterine cervix.

Authors - Sohei Kitazawa
View Article
humanWB

Oncol Lett

Differentiation-related zinc finger protein 750 suppresses cell growth in esophageal squamous cell carcinoma.

Authors - Sheyne Sta Ana Choi
View Article
humanWB

Cell Death Discov

TRIM29 hypermethylation drives esophageal cancer progression via suppression of ZNF750

Authors - Qiyi Yi
View Article