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  • Featured Product
  • KD/KO Validated

RND3 Polyclonal antibody

RND3 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat and More (1)

Applications

WB, IP, IF, ELISA

Conjugate

Unconjugated

Cat no : 12534-1-AP

Synonyms

ARHE, memB, Protein MemB, Rho family GTPase 3, Rho8, RhoE, RND3

Validation Data Gallery

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  • Immunohistochemistry (IHC) staining of human pancreas tissue using RND3 Polyclonal antibody (12534-1-AP)

    IHC staining of human pancreas using 12534-1-AP

    Immunohistochemical analysis of paraffin-embedded human pancreas slide using 12534-1-AP (RND3 Antibody) at dilution of 1:50.

  • Immunohistochemistry (IHC) staining of human pancreas tissue using RND3 Polyclonal antibody (12534-1-AP)

    IHC staining of human pancreas using 12534-1-AP

    Immunohistochemical analysis of paraffin-embedded human pancreas slide using 12534-1-AP (RND3 Antibody) at dilution of 1:50.

Product Information

12534-1-AP targets RND3 in WB, IP, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen RND3 fusion protein Ag3235
Full Name Rho family GTPase 3
Calculated Molecular Weight 244 aa, 27 kDa
GenBank Accession NumberBC012513
Gene Symbol RND3
Gene ID (NCBI) 390
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Rnd3, also known as RhoE, belongs to the Rnd subclass of the Rho family of small guanosine triphosphate (GTP)-binding proteins. Rnd proteins are unique due to their inability to switch from a GTP-bound to GDP-bound conformation. The basic role of Rnd3 is to report as an endogenous antagonist of RhoA signaling-mediated actin cytoskeleton dynamics, which specifically contributes to cell migration and neuron polarity. Rnd3 also plays a critical role in arresting cell cycle distribution, inhibiting cell growth, and inducing apoptosis and differentiation.

Publications

SpeciesApplicationTitle
humanWB,IP

Cancer Res

Small GTPase RhoE/Rnd3 is a critical regulator of Notch1 signaling.

Authors - Zehua Zhu
View Article
humanWB

J Mol Cell Biol

Nanog suppresses cell migration by downregulating thymosin β4 and Rnd3.

Authors - Zhou Yizhuo Y
View Article
RATWB,IF

J Am Heart Assoc

Rnd3 as a Novel Target to Ameliorate Microvascular Leakage.

Authors - Jerome W Breslin
  • KD Validated
View Article
ratWB

Life Sci

Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation.

Authors - Cui Zhai
View Article
humanWB

Mol Cell Biochem

MicroRNA-200b regulates cyclin D1 expression and promotes S-phase entry by targeting RND3 in HeLa cells.

Authors - Xia Wei W
  • KD Validated
View Article
humanWB

Cancer Lett

KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3 down-regulation in hepatocellular carcinoma cells

Authors - Meihua Shan
View Article