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Prothymosin Alpha Polyclonal antibody

Prothymosin Alpha Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IHC, ELISA

Conjugate

Unconjugated

Cat no : 10480-1-AP

Synonyms

Prothymosin alpha, prothymosin, alpha, PTMA, TMSA

Validation Data Gallery

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  • Immunohistochemistry (IHC) staining of human lymphoma tissue using Prothymosin Alpha Polyclonal antibody (10480-1-AP)

    IHC staining of human lymphoma using 10480-1-AP

    Immunohistochemical analysis of paraffin-embedded human lymphoma using 10480-1-AP (Prothymosin alpha antibody) at dilution of 1:100 (under 25x lens).

  • Immunohistochemistry (IHC) staining of human lymphoma tissue using Prothymosin Alpha Polyclonal antibody (10480-1-AP)

    IHC staining of human lymphoma using 10480-1-AP

    Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using 10480-1-AP (Prothymosin alpha antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of human lymphoma tissue using Prothymosin Alpha Polyclonal antibody (10480-1-AP)

    IHC staining of human lymphoma using 10480-1-AP

    Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using 10480-1-AP (Prothymosin alpha antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Tested Applications

Positive IHC detected inhuman lymphoma tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:20-1:200
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

10480-1-AP targets Prothymosin Alpha in IHC, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Prothymosin Alpha fusion protein Ag0732
Full Name prothymosin, alpha
Calculated Molecular Weight 12 kDa
GenBank Accession NumberBC003510
Gene Symbol Prothymosin Alpha/PTMA
Gene ID (NCBI) 5757
RRIDAB_2174388
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Prothymosin alpha (PTMA) is a nuclear protein possessing a number of cellular functions including cell survival. PTMA is identified to be localized in the nuclei of neurons, while it is found in both nuclei and cytoplasm in the astrocytes and microglia of adult brai. PTMA inhibits the neuronal necrosis induced by serum-free starvation or ischemia-reperfusion stress, which causes a rapid internalization of GLUT1/4, leading a decrease in glucose uptake and cellular ATP levels. Extensive research on PTMA showed that it is of clinical significance and potential medical use as they may serve as a molecular marker for cancer prognosis and/or as therapeutic agents for treating immunodeficiencies, autoimmune diseases and malignancies.

Protocols

Product Specific Protocols
IHC protocol for Prothymosin Alpha antibody 10480-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols