PIAS4 AntibodyRabbit Polyclonal
|In-house applications||ELISA, WB Application not tested? Please see our Guarantee.|
|Published applications||WB||Publications||1 citations –view here|
|Species specificity||Human,Mouse,Rat; other species not tested.|
|Positive WB detected in||K-562 cells, HL-60 cells, mouse ovary tissue, mouse pancreas tissue|
|Recommended dilution||WB : 1:500-1:5000|
IP = Immunoprecipitation
|Source||Rabbit||Purification method||Antigen affinity purification|
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Aliquoting is unnecessary for -20oC storage
|Immunogen||PIAS4 fusion protein ag5498||Full name||protein inhibitor of activated STAT, 4|
|BC029874||Gene ID (NCBI)||51588|
|Gene symbol||PIAS4||Synonyms||E3 SUMO protein ligase PIAS4, FLJ12419, PIAS gamma, PIAS4, Piasg, PIASY, ZMIZ6|
PIAS4(protein inhibitor of activated STAT protein 4) is also named as PIASG, PIASy and belongs to the PIAS family. It enhanced the conjugation of SUMO2 to GATA2 through its E3 SUMO ligase activity. TGF-b can up-regulates PLAS4 expression in MCs to down-regulatea-SMA gene transcription by the interaction with E12 and PLAS4 predominantly acts as E3 ligases for E12 in MCs among PIAS family members (PMID:22829926). This protein can be sumoylated and Lys-35 is the main site of sumoylation(PMID:15831457).