PIAS4 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 14242-1-AP

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Freight/Packing

Size: 09µ/gram

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Tested Applications

Applications:
ELISA, WB
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Species specificity:
Human, Mouse, Rat

Positive WB detected in:
K-562 cells, HL-60 cells, mouse ovary tissue, mouse pancreas tissue

Recommended dilution:
WB : 1:500-1:5000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.

Immunogen Information


Full name:
protein inhibitor of activated STAT, 4

Calculated molecular weight:
57 kDa

Observed molecular weight:
57-70kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PIAS4

Synonyms
E3 SUMO protein ligase PIAS4, FLJ12419, PIAS gamma, PIAS4, Piasg, PIASY, ZMIZ6
Background

PIAS4(protein inhibitor of activated STAT protein 4) is also named as PIASG, PIASy and belongs to the PIAS family. It enhanced the conjugation of SUMO2 to GATA2 through its E3 SUMO ligase activity. TGF-b can up-regulates PLAS4 expression in MCs to down-regulatea-SMA gene transcription by the interaction with E12 and PLAS4 predominantly acts as E3 ligases for E12 in MCs among PIAS family members (PMID:22829926). This protein can be sumoylated and Lys-35 is the main site of sumoylation(PMID:15831457).


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