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  • Featured Product
  • KD/KO Validated

LRRC17 Polyclonal antibody

LRRC17 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 20918-1-AP

Synonyms

LRRC17, P37NB

Validation Data Gallery

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  • Western Blot (WB) analysis of HeLa cells using LRRC17 Polyclonal antibody (20918-1-AP)

    WB analysis of HeLa using 20918-1-AP

    HeLa cells were subjected to SDS PAGE followed by western blot with 20918-1-AP (LRRC17 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

  • Western Blot (WB) analysis of mouse heart tissue using LRRC17 Polyclonal antibody (20918-1-AP)

    WB analysis of mouse heart using 20918-1-AP

    mouse heart tissue were subjected to SDS PAGE followed by western blot with 20918-1-AP (LRRC17 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

Tested Applications

Positive WB detected inHeLa cells, mouse heart tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:200-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

The immunogen of 20918-1-AP is LRRC17 Fusion Protein expressed in E. coli.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen LRRC17 fusion protein Ag15117
Full Name leucine rich repeat containing 17
Calculated Molecular Weight 441 aa, 52 kDa
Observed Molecular Weight 52 kDa
GenBank Accession NumberBC027903
Gene Symbol LRRC17
Gene ID (NCBI) 10234
RRIDAB_2878763
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen Affinity purified
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Leucine-rich repeat-containing protein 17 (LRRC17) is an LRR protein predominantly expressed by osteoblasts. LRRC17 acts as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation (PMID: 19336404). It has been reported that low plasma level of LRRC17 is an independent risk factor for osteoporotic fractures (PMID: 27355564).

Protocols

Product Specific Protocols
WB protocol for LRRC17 antibody 20918-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

Redox Biol

LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss.

Authors - Fei Liu
View Article
humanWB

Exp Ther Med

LRRC17 regulates the bone metabolism of human bone marrow mesenchymal stem cells from patients with idiopathic necrosis of femoral head through Wnt signaling pathways: A preliminary report.

Authors - Da Song
  • KD Validated
View Article