Lamin B1 Antibody 75 Publications

Rabbit Polyclonal| Catalog number: 12987-1-AP

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Size: 09µ/gram

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Species specificity:
human, mouse, rat, zebrafish

Positive WB detected in:
HeLa cells, NIH/3T3 cells; mouse lung tissue; Y79 cells; SH-SY5Y cells; mouse eye tissue; human brain tissue; K-562 cells; rat brain tissue; mouse brain tissue; rat heart tissue; U-937 cells; HepG2 cells; mouse spleen tissue; mouse pancreas tissue; mouse kidney tissue; Jurkat cells; human kidney tissue

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human breast cancer tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HEK-293 cells

Recommended dilution:
WB : 1:500-1:5000
IP : 1:500-1:5000
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
lamin B1

Calculated molecular weight:
66 kDa

Observed molecular weight:
66-70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
LMNB1

Synonyms
ADLD, lamin B1, LMN, LMN2, LMNB, LMNB1
Background

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Expression of uncleavable mutant lamin A or B caused significant delays in the onset of chromatin condensation and nuclear shrinkage during apoptosis(PMID:11953316). This protein is not suitable for samples where the nuclear envelope has been removed.


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