HABP2 Antibody
Rabbit Polyclonal
Catalog number: 12863-1-AP
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Applications
| Tested applications | ELISA, WB, IF |
| Cited applications | |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | |
| Positive WB detected in | human kidney tissue |
| Positive IF detected in | HepG2 cells |
| Recommended dilution | WB: 1:500-1:5000 IF: 1:20-1:50 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
human kidney tissue were subjected to SDS PAGE followed by western blot with 12863-1-AP(HABP2 Antibody) at dilution of 1:1500
Immunofluorescent analysis of HepG2 cells, using HABP2 antibody 12863-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | HABP2 fusion protein ag3981 | Full name | hyaluronan binding protein 2 |
|
Calculated molecular weight |
560aa,63kd |
Observed molecular
weight |
39kd |
|
GenBank accession number |
BC031412 | Gene ID (NCBI) | 3026 |
| Gene symbol | HABP2 | Synonyms | FSAP; HABP; HGFAL; PHBP |
Background
HABP2 is also named as HGFAL, PHBP and belongs to the peptidase S1 family. It can activate coagulation factor VII and prourokinase and release the vasoactive peptide bradykinin by cleaving kininogen and is an important role in the regulation of the haemostasis system as well as fibroproliferative inflammatory processes(PMID:21655671). HABP2 is present as the 70 kDa inactive single chain precursor in human plasma and transforms to the active two chain form, 50 kDa heavy chain and 27 kDa light chain,and the 50 kDa heavy chain changes to two 26 kDa fragments, and 27 kDa light chain to 17 kDa and 8 kDa fragments, which are all bridged by disulfide linkages, by autocleavage(PMID:11217080). This antibody is specific to HABP2. |
