H3F3B Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 10265-1-AP

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Freight/Packing

Con: 23 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, HEK-293 cells

Recommended dilution:
WB : 1:200-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
H3 histone, family 3B (H3.3B)

Calculated molecular weight:
15 kDa

Observed molecular weight:
17 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
H3F3B

Synonyms
H3 histone, family 3B (H3.3B), H3.3A, H3.3B, H3F3, H3F3A, H3F3B, Histone H3.3
Background

Histones are the basic nuclear proteins responsible for the nucleosome structure of the chromosomal fiber. Five classes of histone genes have been reported, some of which are expressed only during S phase, while others are replication independent. The latter are referred to as replacement histones and are expressed in quiescent or terminally differentiated cells. H3F3B is one replacement histone [PMID: 8586426]. It constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Thereby it has a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability [PMID: 14718166, 15776021].


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