Histone H2A.X Antibody 8 Publications

Rabbit Polyclonal| Catalog number: 10856-1-AP

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Size: 09µ/gram

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Species specificity:
Human, Mouse, Rat

Positive WB detected in:
Raji cells, HEK-293 cells, HL-60 cells, mouse heart tissue

Positive IHC detected in:
human lymphoma tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:200-1:2000
IHC : 1:50-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.

Immunogen Information


Full name:
H2A histone family, member X

Calculated molecular weight:
15 kDa

Observed molecular weight:
15-18 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
H2AFX

Synonyms
H2A histone family, member X, H2A.X, H2A/X, H2AFX, H2AX, Histone H2A.x
Background

Histone H2A.X belongs to the histone H2A family, which is synthesized in G1 and S phase. It is involved in nucleosomal organization of chromatin together with other histone proteins, and is specially important for recombination between immunoglobulin switch regions. H2A.X becomes phosphorylated on serine 139 (to form gamma-H2AFX or H2AX139ph) in response to DNA double strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks, which promotes DNA repair and maintains genomic stability.


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