ERO1L Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 12007-1-AP

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Size: 09µ/gram

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Species specificity:
Human, Mouse, Rat

Positive WB detected in:
mouse ovary tissue, A431 cells

Positive IP detected in:
L02 cells

Positive IHC detected in:
human pancreas cancer tissue

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:200-1:1000
IP : 1:200-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.

Immunogen Information


Full name:
ERO1-like (S. cerevisiae)

Calculated molecular weight:
468aa,54 kDa

Observed molecular weight:
54 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ERO1L

Synonyms
ERO1 alpha, ERO1 L, ERO1 L alpha, ERO1 like (S. cerevisiae), ERO1 like protein alpha, ERO1L, Oxidoreductin 1 L alpha
Background

ERO1L, also named as ERO1-alpha, is an essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. It acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. It does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Glutathione may be required to regulate its activity in the endoplasmic reticulum. It may be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress. It is required for the folding of immunoglobulin proteins. Responsible for the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. This antibody has no cross reaction to ERO1L.


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